Fluoride and endocrine disruptor associated with Thyroid Dysfunction
By The Fluoride Action Network
It has been established that fluoride has the ability to alter your endocrine function, yet this fact is being ignored by the agencies and associations that continue to promote the practice of water fluoridation.
According to a 2006 report by the National Research Council of the National Academies1 , fluoride is “an endocrine disruptor in the broad sense of altering normal endocrine function.”
This altered function can involve your thyroid, parathyroid, and pineal glands, as well as your adrenals, pancreas, and pituitary.
Your thyroid gland and its associated hormones are responsible for maintaining your body’s overall metabolic rate, and for regulating normal growth and development. As all metabolically active cells require thyroid hormone for proper functioning, disruption of this system can have a wide range of effects on virtually every system of your body. Thyroid dysfunction is considered among the most prevalent of endocrine diseases in the United States.
Historical Use of Fluoride as a Medical Intervention for Hyperthyroid
Up until the 1970s, scientists in Europe prescribed fluoride to reduce the basal metabolism rate in patients with an over-active thyroid gland. One published clinical study from this period reported that doses of just 2 to 3 milligrams of fluoride—a dose that many, if not most, Americans now receive on a regular basis—were sufficient to reduce thyroid activity in hyperthyroid patients.
The use of fluoride as an anti-thyroid treatment was prompted by research beginning in the 1800s2 linking fluoride ingestion to goiter, a swelling of the thyroid gland resulting from a hypothyroid condition.
In its 2006 report Fluoride in Drinking Water: A Scientific Review of EPA’s Standards, the National Research Council (NRC) reported that “several lines of information indicate an effect of fluoride on thyroid function.”
Specifically, the report discussed research showing that:
“fluoride exposure in humans is associated with elevated TSH concentrations, increased goiter prevalence, and altered T4 and T3 concentrations” with “similar effects on T4 and T3…reported in experimental animals.”
In addition, the NRC discussed research linking fluoride to impacts on parathyroid activity, impairment of glucose tolerance, and possibly the timing of sexual maturity.
In light of these findings, the NRC panel recommended that the “effects of fluoride on various aspects of endocrine function should be examined further, particularly with respect to a possible role in the development of several diseases or mental states in the United States”3. Despite this, proponents of fluoridation continue to ignore the scientific literature concerning the detrimental effects that fluoride has on the endocrine system.
Surprisingly Tiny Amounts of Fluoride Can Change Your Thyroid Function
Altered thyroid function is associated with fluoride intakes as low as 0.05-0.1 mg fluoride per kilogram body weight per day (mg/kg/day), or 0.03 mg/kg/day with iodine deficiency. Increased prevalence of goiter (>20 percent) is associated with fluoride intakes of 0.07-0.13 mg/kg/day, or 0.01 mg/kg/day with iodine deficiency.4
For a 70 kg (154 pound) adult, this means that 3.5 mg fluoride per day (or 0.7 mg fluoride per day with iodine deficiency) could result in thyroid dysfunction. The most recent exposure analysis by the U.S. Environmental Protection Agency5 estimates that the average American adult is consuming nearly 3 mg fluoride on a daily basis, and some are routinely ingesting 6 mg per day or more.
Even more concerning, however, are the doses of fluoride in children.
For a 14 kg (30 pound) child, fluoride intakes greater than 0.7 mg per day (or 0.14 mg per day with iodine deficiency) puts the child at risk for endocrine dysfunction. The EPA (2010) estimates children within this weight range (1-3 year-olds) consume over 1.5 mg fluoride each day, or more than twice the amount necessary to induce altered thyroid function, even with an adequate iodine intake.
These chronic exposures could have profound and life-long effects on the intellectual, social, sexual and overall physical development of children.
Numerous studies have found a relationship between relatively low to moderate levels of fluoride exposure and reduced IQ in children6 . Even fluoride levels of less than 1.0 mg/L have been associated with reduced IQ and increased frequency of hypothyroidism in children experiencing iodine deficiency7.
Iodine Deficiency, Fluoride, and Thyroid Disease
Iodine is necessary for proper functioning of your thyroid gland. As your body cannot produce its own iodine, it must be obtained from your diet. Iodine is sequestered into your thyroid gland, where it is incorporated into the thyroid hormones thyroxine (T4) or triiodothyronine (T3). In healthy individuals these hormones are precisely regulated by thyroid-stimulating hormone (TSH), and are required by all metabolically active cells in your body.
Iodine deficiency is known to be responsible for a variety of disorders—including hypothyroidism, goiter, and disturbances of physical and mental development. According to recent research, “normal” dietary intake of iodine is 100-150 mcg per day, however greater amounts of iodine are recommended for pregnant and lactating women, as studies have shown that the most detrimental effects of iodine deficiency occur during fetal and neonatal growth.
The primary sources of iodine are saltwater fish and seaweed, with grains providing trace amounts. An estimated 2.2 billion people worldwide are at risk for iodine deficiency8. Many countries have introduced iodine supplements into the food supply to combat deficiencies, such as has been done with table salt in the United States, where iodine deficiency is generally no longer considered a problem.
However, data suggest that iodine intakes have decreased over the past few decades9. Although this decline may have stabilized in recent years10, more than 11 percent of all Americans—and more than 15 percent of American women of child-bearing age—presently have urine iodine levels less than 50 mcg/L11, indicating moderate to severe iodine deficiency. An additional 36 percent of reproductive-aged women in the U.S. are considered mildly iodine deficient (<100 mcg/L urinary iodine).
Considering the importance of iodine for proper functioning of your thyroid gland, and the importance of your thyroid gland for proper functioning of your entire body, any disturbances to this delicate balance must be seriously considered. Your thyroid gland may be the most sensitive tissue in your body to fluoride12, with more fluoride accumulating in your thyroid than many other soft tissues13.
Fluoride may directly or indirectly interfere with proper functioning of your thyroid gland, with potential actions including fluoride’s ability to:
Mimic thyroid-stimulating hormone (TSH)
Disrupt sensitive G-proteins, which serve as the building blocks of your body’s hormone receptors
Damage the cells of your thyroid gland
Damage your DNA14
Disrupt conversion from the inactive form of the thyroid hormone (T4) to the active form (T3)
Inadequate diet—including deficiencies in iodine, calcium and protein—can play a key role in fluoride-induced thyroid dysfunction. For someone with a deficient diet and/or an already compromised thyroid gland, any of the detrimental effects of fluoride exposure on the thyroid system, and thus the entire body, will likely be compounded. In fact, in one 2005 study, Gas’kov et al.15 determined that even an increased intake of iodine would not be sufficient to counter the adverse effects of excessive fluoride exposure on the thyroid gland in children.
When the function of your thyroid gland is suppressed, your body cannot produce or maintain adequate levels of T3 and T4, resulting in a condition known as hypothyroidism.
Hypothyroidism is Pervasive Among Women
According to PubMed Health, women over the age of 50 are at the highest risk for developing hypothyroidism, or under-active thyroid. Nearly 4 percent of the U.S. population (over 11 million people) have overt hypothyroidism.16 Perhaps an additional 10 percent of the general population (21 million people) have subclinical hypothyroidism, which is considered a strong risk factor for later development of overt hypothyroidism.
It is important to understand that even these surprisingly large numbers likely vastly underreport the number of women that are affected as they rely on outdated criteria to diagnose hypothyroidism.
The frequency of hypothyroidism tends to increase with age—one 2010 study estimates that up to 20 percent of older age groups have some form of hypothyroidism. Synthroid and Armour, both pharmaceuticals used to treat hypothyroidism, were the 7th and 73rd top selling drugs in the United States in 2009, with over 24 million combined units sold.
Symptoms of hypothyroidism are numerous, and may include:
fatigue, loss of energy, general lethargy
muscle and/or joint pain
coarse or dry skin and hair
carpal tunnel syndrome
forgetfulness, impaired memory, inability to concentrate
weakness in extremities
bradycardia (reduced heart rate)
fullness in the throat, hoarseness
increased risk of heart disease
increased “bad” cholesterol (LDL)
Despite a higher incidence in older populations, the rate of primary (neonatal) congenital hypothyroidism has increased by nearly 75 percent over the past two decades in the United States, now affecting 1 in every 2,370 births17. Untreated neonatal hypothyroidism can lead to mental retardation, growth retardation, and heart problems. Children with congenital or juvenile hypothyroidism have been reported to have delayed eruption of teeth and/or enamel defects, although the connection between these findings and the impact of fluoride on the thyroid has not been studied18.
Also extremely concerning is the inverse relationship between the severity of subclinical hypothyroidism in pregnant women and the reduced IQ of their children19. Maternal subclinical hypothyroidism has also been proposed as a cause or contributor in the development of autism20.
Fluoride’s potential to impact the thyroid gland highlights, yet again, the need for a precautionary approach to the indiscriminate use of fluorides. The deliberate addition of fluoride to public drinking water supplies is particularly problematic, as it exposes your entire body—not just your teeth—to a biologically-active substance, without regard to individual need or sensitivity, and thereby violates key principles of modern pharmacology.
Important! The producers of this powerful film are allowing a full and FREE preview
through August 13th in celebration of Fluoride Awareness Week (Aug 7 – 13)! You can support Fluoride Action Network by purchasing the Professional Perspectives DVD at a special price of $10 during Fluoride Awareness Week.
What You Can Do TODAY!
The Fluoride Action Network has a game plan to END water fluoridation in both Canada and the United States, and this Fluoride Awareness Week will hopefully bring us a lot closer to that goal by spreading mass awareness. We’re pleased to report that during Fluoride Awareness Week, yet another city, Philomath in Oregon, decided to remove fluoride from their water supply! Proof again that there is hope for change in your city, and you CAN make it happen. Our fluoride initiative is primarily focused on Canada since 60 percent of Canada is already non-fluoridated. If we can get the rest of Canada to stop fluoridating their water, we believe the U.S. will be forced to follow. Please, join the anti-fluoride movement in Canada, New Zealand and the United States by contacting the representative for your area below. If you are a mom and want to see an end to water fluoridation, you can also contact a new group called “Moms Against Fluoridation” by sending an email to: info@MomsAgainstFluoridation.org.
Contact Information for Canadian Communities:
If you live in Ontario, Canada, please join the ongoing effort by contacting Diane Sprules at email@example.com.
The point-of-contact for Toronto, Canada is Aliss Terpstra. You may email her at firstname.lastname@example.org.
Contact Information for American Communities:
We’re also going to address three US communities: New York City, Austin, and San Diego:
New York City, NY: With the recent victory in Calgary, New York City is the next big emphasis. The anti-fluoridation movement has a great champion in New York City councilor Peter Vallone, Jr. who introduced legislation on January 18 “prohibiting the addition of fluoride to the water supply.” A victory there could signal the beginning of the end of fluoridation in the U.S. If you live in the New York area I beg you to participate in this effort as your contribution could have a MAJOR difference. Remember that one person can make a difference. The point person for this area is Carol Kopf, at the New York Coalition Opposed to Fluoridation (NYSCOF). Email her at NYSCOF@aol.com . Please contact her if you’re interested in helping with this effort.
Austin, Texas: Join the effort by contacting Rae Nadler-Olenick at either: email@example.com or firstname.lastname@example.org, or by regular mail or telephone: POB 7486
Austin, Texas 78713
Phone: (512) 371-3786
San Diego, California: Contact Patty Ducey-Brooks, publisher of the Presidio Sentinel at email@example.com .
Contact Information for New Zealand Communities:
New Zealand: Contact Mary Byrne if you would like to be involved in stopping fluoridation in New Zealand. Mary would like to hear from you! Email her at: firstname.lastname@example.org
In addition, you can:
Tell the EPA you expect them to uphold their duty to protect you and your children from this toxic food fumigant.
Make a generous tax-deductible donation to the Fluoride Action Network, to help them fight for your rights to fluoride-free food and water.
Check out FAN’s Action Page, as they are working on multiple fronts to rid our food and water supplies of fluoride.
For timely updates, join the Fluoride Action Network Facebook page.
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4 National Research Council. 2006. Fluoride in Drinking Water: A Scientific Review of EPA’s Standards. National Academies Press: Washington, DC.
5 EPA (U.S. Environmental Protection Agency). 2010. Fluoride: Exposure and Relative Source Contribution Analysis. Health and Ecological Criteria Division. Office of Water. Washington, D.C.
6 Connett P, Beck J, Micklem HS. 2010. The Case Against Fluoride. How Hazardous Waste Ended Up in Our Drinking Water and the Bad Science and Powerful Politics That Keep It There. Chelsea Green Publishing: White River Junction, VT. 372 Pp. / Ding Y, Gao Y, Sun H, et al. 2011. The relationships between low levels of urine fluoride on children’s intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. J Hazard Mater. Feb 28;186(2-3):1942-6. / Xiang Q, Liang Y, Chen B, et al. 2010. Serum fluoride level and children’s Intelligence Quotient in two villages in China. Env Health Persp (Online 17 Dec 2010). doi:10.1289/ehp.1003171.
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